The superfamily of proteins with von Willebrand factor type A-like domains: one theme common to components of extracellular matrix, hemostasis, cellular adhesion, and defense mechanisms.
نویسندگان
چکیده
منابع مشابه
Von Willebrand factor, hemostasis and inflammation.
For many decades, hemostatic and immune defense mechanisms were thought to act independently. More recently, this concept has been revised largely. Thus, it is becoming apparent that platelets, like leukocytes, have multiple functions in innate and adaptive immunity, changing their role from “innocent bystanders” to integral players in inflammatory or infectious processes and immunity (1, 2). F...
متن کاملاهمیت فیبرونکتین در تکوین، ترمیم و درمان: مقاله مروری
Fibronectin (FN) is one of the essential component of the extra cellular matrix and their important role is as regulator of cellular activities and also fibronectin is an important scaffold for maintaining tissue. Fibronectin conformational changes expose additional binding sites that participate in fibril formation and in conversion of fibrils into a stabilized, insoluble form. In fact fibrone...
متن کاملEssay Distribution and Evolution of von Willebrand/Integrin A Domains: Widely Dispersed Domains with Roles in Cell Adhesion and Elsewhere□D
The von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in extracellular matrix proteins, and in integrin receptors. A number of human diseases arise from mutations in VWA domains. We have analyzed the phylogenetic distribution of this domain and the relationships among 500 proteins containing this domain. Although the majority of VWAcontaining proteins are extrace...
متن کاملDistribution and Evolution of von Willebrand/Integrin A Domains: Widely Dispersed Domains with Roles in Cell Adhesion and Elsewhere□D
The von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in extracellular matrix proteins, and in integrin receptors. A number of human diseases arise from mutations in VWA domains. We have analyzed the phylogenetic distribution of this domain and the relationships among 500 proteins containing this domain. Although the majority of VWAcontaining proteins are extrace...
متن کاملDistribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere.
The von Willebrand A (VWA) domain is a well-studied domain involved in cell adhesion, in extracellular matrix proteins, and in integrin receptors. A number of human diseases arise from mutations in VWA domains. We have analyzed the phylogenetic distribution of this domain and the relationships among approximately 500 proteins containing this domain. Although the majority of VWA-containing prote...
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عنوان ژورنال:
- Blood
دوره 77 11 شماره
صفحات -
تاریخ انتشار 1991